What is chloroquine resistance

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  1. Pimply User

    What is chloroquine resistance


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. Chloroquine resistance is widespread. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. Chloroquine resistance is widespread and, at present, is particularly prominent in various parts of the world including sub- Saharan Africa, Southeast Asia, the Indian subcontinent, and over large portions of South America, including the Amazon basin 1.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    What is chloroquine resistance

    Chloroquine and Proguanil - Superdrug Health Clinic, Aralen chloroquine Malaria Drug Side Effects & Dosage

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  4. Chloroquine, synthetic drug used in the treatment of malaria. Chloroquine, introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine phosphate.

    • Chloroquine drug Britannica.
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    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine became the drug of first choice in malaria therapy for more than two decades until resistance limited the use of the drug. The resistance is correlated to point mutations in the gene pfcrt 26. The gene codes for a transporter PfCRT. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen.

     
  5. Ferrari0408 New Member

    Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1]. Aralen chloroquine Malaria Drug Side Effects & Dosage Inhibition of autophagy with bafilomycin and chloroquine. Chloroquine Mechanism of drug action and resistance in.
     
  6. FoY User

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Feb 19, 2020 PLAQUENIL does not prevent relapses of P. vivax or P. ovale because it is not active against the hypnozoite forms of these parasites. For radical cure of P. vivax and P. ovale infections, concomitant therapy with an 8-aminoquinoline compound is necessary.

    Hydroxychloroquine Uses, Dosage & Side Effects -