In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil lethargy Chloroquine phosphate freshwater fish Most people do not experience side effects from taking Plaquenil. Among those who do, common side effects include nausea, stomach cramps, dizziness, headaches, and diarrhea. These side effects often decrease over time. Plaquenil can cause serious eye problems, especially if taken at high doses or for longer than five years. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Plaquenil itself probably does not have a direct affect on your immune system - it is a DMARD and is not considered to be an immunosuppressant. However, many with active autoimmune diseases feel that they are not succeptible to many of the common viruses that they are exposed to - somewhat of a silver lining. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Is gastrointestinal problems common from plaquenil Plaquenil and stomach issues." Lupus Community., Plaquenil Oral Uses, Side Effects, Interactions. Can hydroxychloroquine cause erectile dysfunctionJoint pain after stopping plaquenilMuscle weakness with plaquenilHydroxychloroquine sulphate tablets uses Gastrointestinal involvement is common in patients with systemic lupus erythematosus SLE, and up to 40 percent of patients have gastrointestinal manifestations during their lifetime. These manifestations may be due to vasculitis, side-effects of the medications used to treat SLE, infection, or other intercurrent processes eg, uremia. REFERENCES - UpToDate. Anyone on Hydroxychloroquine plaquenil - Autoimmune.. Stomach problems with Plaquenil • Johns Hopkins Arthritis Center. One of the problems with Plaquenil is that because it's so slow to act, the improvements are also slow and subtle. So most people don't realize that they've improved until they STOP taking it. I've been on it twice, along with Atabrine another antimalarial. In my case, it never worked so I didn't notice a change. Feb 13, 2020 Gastrointestinal pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Humira, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. I had severe nausea and diarrhea when started on Plaquenil 2 X 200mg tabs once daily almost 3yrs ago. As I also have Crohn's Disease and an Ileostomy this was putting me at serious risk. I was told to stop the Plaquenil until my GI symptoms disappeared.