B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Arthritis and hydroxychloroquine Why chloroquine It may initially help a bruise from worsening, but it rarely has a benefit on a bruise after the first 24 hours,” Dr. Friedler says. “After that time, heat can sometimes help the bruise. Rheumatoid arthritis RA mainly affects the joints. But it, and many of the medications that treat it, can also affect the you recognize any of these problems? Rheumatoid Nodules. About 1. I've started to get really tender shins and bruising for no reason on my legs. I've seen my gp and they are miffed and have done some blood tests. I have alot of fatigue and my legs feel heavy, im on plaquenil and nifidipine for raynauds. has anyone else had this? B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Bruising on shin from plaquenil Bruising easily? Plaquenil? Just lupus in general? lupus, Rheumatoid Arthritis Skin Problems Nodules, Rashes, and More Chloroquine for giardiasisRemove chloroquine phosphateDoes plaquenil help osteoarthritis When your blood takes longer to clot, more of it leaks from your blood vessels and accumulates under your skin. If your bruising is tied to medication overuse, you may also experience gas. bloating. stomach pain. heartburn. nausea. vomiting. Random Bruising 13 Possible Causes Excluding Obvious Injury. Unexplained bruising DailyStrength. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil and Increased tendency to bruise - from FDA reports Summary Increased tendency to bruise is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months, also take medication Enbrel, and have Osteoporosis. Plaquenil, systemic lupus erythematosus, bruising, skin. I have been taking the drug for almost two year for Sjogrens syndrome/lupus and recently I have noticed unexplainable brusing on my back and thighs. Applies to hydroxychloroquine oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.