In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Chloroquine phosphate pregnancy Plaquenil for alopecia areata Chloroquine phosphate drug study Optometry plaquenil dosage retinopathy J Eur Acad Dermatol Venereol. 2006 Apr;204487-8. Hydroxychloroquine-induced pigmentation in two patients with systemic lupus erythematosus. Blue–grey pigmentation of the skin affects up to 25% of patients taking hydroxychloroquine, especially where there has been bruising. Transverse pigmented nail bands and mucosal pigmentation have also been reported. Rashes may occur in up to 10% of patients, most commonly morbilliform or psoriasiform. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one., Hydroxychloroquine DermNet NZ Plaquenil and psoriasisStopped taking plaquenilAnyone developed kidney stone while on hydroxychloroquineAao plaquenil guidelines Conclusions HCQ-induced pigmentation is considered uncommon adverse effect of HCQ, with a prevalence rate of 49.2% indicated in this study. Furthermore, history of bruising, sun exposure, and the presence of mucous membrane pigmentation are possible predisposing factors. Prevalence and risk factors of hyperpigmentation induced by.. Skin Pigmentation with Hydroxychloroquine Plaquenil — Donovan Hair Clinic. Hydroxychloroquine induced cutaneous pigmentation a unique pattern. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. Microscopic examination shows yellow- to brown-colored pigment granules in macrophages and fibroblasts and among collagen fibers47, 49; the pigment granules react for iron and some of them for melanin.15, 47 In 2 cases of hydroxychloroquine-associated skin pigmentation, only melanin was identified, 51 and in another 5 cases, melanin and ferric iron 6 were observed. HCQ is often prescribed for longer durations and may be associated with cutaneous adverse effects such as yellow-brown or slate-grey pigmentation, bleaching of hair, exacerbation of pre-existing psoriasis, cutaneous rashes and pruritus. 1 Cutaneous pigmentation occurs in 10%–30% patients, most commonly over shins.