Saposin b binds chloroquine

Discussion in 'Aralen 250 Mg' started by Katyu_sha, 14-Mar-2020.

  1. ak65 User

    Saposin b binds chloroquine


    Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects.

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    Atovaquone is a front-line antimalarial drug that functions by competitively inhibiting binding of coenzyme Q10 to the cytochrome bc1 complex. Atovaquone is administered orally, but has low solubility and is poorly absorbed with high variability in bioavailability. Title = "The Lysosomal Protein Saposin B Binds Chloroquine", abstract = "Chloroquine CQ has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. The team was pleasantly surprised to find that saposin B does bind chloroquine. This result was unexpected because saposin B is known to bind lipids—and chloroquine is not a lipid.

    While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone.

    Saposin b binds chloroquine

    Brian Huta - Adjunct Assistant Professor of Chemistry., The Lysosomal Protein Saposin B Binds Chloroquine[email protected]

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  7. Saposin B SapB is a human lysosomal protein, critical for the degradation of O-sulfogalactosylceramide sulfatide. SapB binds sulfatide and presents it to the active site of the enzyme arylsulfatase A. Deficiency of SapB leads to fatal activator-deficient metachromatic leukodystrophy. Given the conformational flexibility and the large hydrophobic “pocket” produced upon physiologically.

    • Exploring the Multiligand Binding Specificity of Saposin B..
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    I am also interested in the origins of drug toxicity as it pertains to lysosomal Saposin proteins see Tinklepaugh J, Smith BM, Hanlon E, Zubieta C, Bou-Abdallah F, Doyle RP. Exploring the Multi-ligand Binding Specificity of Saposin B Reveals Two Binding Sites. ACS Omega. The Lysosomal Protein Saposin B Binds Chloroquine. Huta BP, Mehlenbacher MR, Nie Y, Lai X, Zubieta C, Bou-Abdallah F, Doyle RP ChemMedChem, 113277-282, Feb 04, 2016 However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B sapB, critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity.

     
  8. mike2007 Moderator

    Hiking and biking in the parks and woodlands are popular outdoor activities, but some native plants can quickly turn your outing into a miserable experience. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Rheumatoid Arthritis Skin Problems Nodules, Rashes, and More Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  9. debesha Guest

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Chloroquine Davis's Drug Guide for Rehabilitation. Hydroxychloroquine Uses, Dosage & Side Effects - Hydroxychloroquine Plaquenil Side Effects & Dosage for.
     
  10. Doctorrr Well-Known Member

    Plaquenil and loss of appetite - Lupus - MedHelp Yes, Plaquenil causes both weight loss and loss of appetite. Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process.

    Hair Loss from taking Plaquenil? -
     
  11. break New Member

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version.

    Chloroquine - Trade Names