Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects. Plaquenil and irritable bowel syndrome Plaquenil maculopathy screening Atovaquone is a front-line antimalarial drug that functions by competitively inhibiting binding of coenzyme Q10 to the cytochrome bc1 complex. Atovaquone is administered orally, but has low solubility and is poorly absorbed with high variability in bioavailability. Title = "The Lysosomal Protein Saposin B Binds Chloroquine", abstract = "Chloroquine CQ has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. The team was pleasantly surprised to find that saposin B does bind chloroquine. This result was unexpected because saposin B is known to bind lipids—and chloroquine is not a lipid. While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone. Saposin b binds chloroquine Brian Huta - Adjunct Assistant Professor of Chemistry., The Lysosomal Protein Saposin B Binds Chloroquine — [email protected] Plaquenil tb riskDownes sm hydroxychloroquine retinopathyConcordia plaquenilHydroxychloroquine corneal verticillataBenefit of hydroxychloroquine Saposin B SapB is a human lysosomal protein, critical for the degradation of O-sulfogalactosylceramide sulfatide. SapB binds sulfatide and presents it to the active site of the enzyme arylsulfatase A. Deficiency of SapB leads to fatal activator-deficient metachromatic leukodystrophy. Given the conformational flexibility and the large hydrophobic “pocket” produced upon physiologically. Exploring the Multiligand Binding Specificity of Saposin B.. Chemists expose side effects of antimalarial drug. Structural and membrane‐binding properties of saposin D.. I am also interested in the origins of drug toxicity as it pertains to lysosomal Saposin proteins see Tinklepaugh J, Smith BM, Hanlon E, Zubieta C, Bou-Abdallah F, Doyle RP. Exploring the Multi-ligand Binding Specificity of Saposin B Reveals Two Binding Sites. ACS Omega. The Lysosomal Protein Saposin B Binds Chloroquine. Huta BP, Mehlenbacher MR, Nie Y, Lai X, Zubieta C, Bou-Abdallah F, Doyle RP ChemMedChem, 113277-282, Feb 04, 2016 However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B sapB, critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity.