Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil grapefruit Plaquenil rash wont go away Efficacy of plaquenil treatment for rheumatoid arthritis Chloroquine phosphate where to buy Plaquenil hydroxychloroquine and prednisone are used to treat symptoms of rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Prednisone is also used to treat or manage many conditions. Prednisone can potentially interact with certain other medications. Some of these medicines that may lead to prednisone drug interactions include Barbiturates, including Amobarbital Amytal ® Butalbital Fioricet ®, Fiorinal ® Pentobarbital Nembutal ® Phenobarbital Luminal ® Secobarbital Seconal ® It has been reported that levels of anti nuclear antibody reduced by upto 43 % in compliant use of prednisone and plaquenil and is also used to measure treatment response. Double stranded DNA levels however are effected less. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Prednisone and hydroxychloroquine interaction Methotrexate & Prednisone Side-effects? - LUPUS UK, Prednisone Drug Interactions - Drugs Home Page Hydroxychloroquine copay assistance program Our Prednisone Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects of Prednisone Prednisone Tablets, USP.. Does Plaquenil interact with Prednisone?. Plaquenil Oral Interactions with Other Medication. The prednisone began workiing in 3 days and helped reduce my joint inflammation. I had some issues with the plaquenil, nausea and extremity swelling. My rheumy told me that he has never had anyone have leg and hand swelling on plaquenil but he does not doubt it is from the plaquenil. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Alcohol can worsen some side effects of prednisone, such as immune system suppression, bone weakening, and weight gain. It is best to speak with a doctor to avoid serious complications.